Abstract
Summary
The action of two or more inhibitors, each of which acts on the same metabolic sequence but upon different enzymes within a limited portion of the sequence, was defined as sequential blocking. As a model of such a system, the combined action of malonate and fluoroacetate was studied in vivo. It was shown that malonate decreased citrate formation to varying degrees in thymus, kidney, spleen and brain, but increased citrate formation in heart following the injection of fluoroacetate into rats.
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