Abstract
Summary
Sodium monofluoroacetate was administered to Holtzman white rats in doses ranging from 0.3 to 50 mg per kg, and the citrate content of kidney, thymus, brain, spleen, heart, liver and tumors was determined at times ranging from 20 minutes to 48 hours. As in previous studies liver and tumors did not accumulate citrate, but the remaining tissues did, with the maximum occurring in all cases with a dose of 3.5 mg per kg at 3 to 6 hours after the injection. As a standard procedure this dose was recommended for the study of certain phases of the metabolism of individual tissues in vivo.
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