Retardation of Tumor Growth in Mice by Oral Administration of Methyl Androstenediol and Methyl Testosterone

Abstract

Summary

The growth of sarcoma 180 or adenocarcinoma C3H-BA is markedly retarded in mice by oral administration of methyl androstenediol or methyl testosterone in doses approximating 100 mg/kg daily, when treatment is started the day following implantation. Inhibition of sarcoma 37 and adenocarcinoma EO-771, under similar conditions, is slight and of short duration. No retardation of growth of sarcoma 180 was noted when 100 mg/kg doses of the compounds were administered daily by subcutaneous injection.