Abstract
Summary
Castration of male white rats resulted in a decreased rate of phosphopyruvic acid formation from 3-phosphoglyceric acid, by dilute tissue homogenates. Ovariectomy caused an elevation of enzyme activity in the tissues of females. Enzyme activity of hy-pophysectomized rats decreased only 14 days after the operation. The effect of age on this enzyme reaction was also demonstrated. Tissues of young females had a higher enzyme activity than those of mature females, except the ovaries which were considerably lower than in the mature animals. The effect of age was not noticeable in young males. Injection of diethyl stilbestrol in young males or testosterone in young females caused a decrease in phosphopyruvic acid formation. Cortisone and ACTH decreased the rate of this enzyme reaction in both sexes.
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