Abstract
Summary
Trimethylammoniumacethydrazone hydrochloride of L-adrenochrome (T.A.L.) is a potent hemostatic agent. It shares this property with the parent substance adrenochrome, but surpasses it by stability and solubility in aqueous solution. It may be injected intramuscularly in children in amounts of 10 mg without producing local reactions. A single injection of this amount shortens the bleeding time, as measured by Ivy's method, by an average of 38% in 32 subjects; except for 7 non-responsive cases with short pre-injection bleeding time, the mean bleeding time in the remaining 25 cases is cut in half. Only individuals with a short bleeding time fail to respond. Control tests show that the concomitant surgical intervention has no influence on bleeding time.
Get full access to this article
View all access options for this article.