Effects of Feeding Autoclaved Pancreas to Depancreatized and Duct-Ligated Dogs. ∗

Abstract

Conclusions

1. The daily oral administration of 200 g of beef pancreas autoclaved at 15 lb for 15 to 30 minutes was found to be effective in relieving and in preventing fatty infiltration of the liver and other manifestations of lipocaic deficiency in 6 depancreatized and 8 dogs with ligated pancreatic ducts. 2. Autoclaved liver, brain, and salivary glands were found to be ineffective under similar conditions. 3. There is a specific heat resistant substance in pancreas, lipocaic, not found in other tissues, which is effective on oral administration in relieving the residual deficiency in insulin treated depancreatized dogs.