Production of Hypertension Following Choline Deficiency in Weanling Rats. ∗

Abstract

Summary

Of 28 weanling rats surviving a 5-day choline-deficient diet and maintained on a normal diet for 6 months thereafter 20 animals or 71% had arterial blood pressure levels over 150 mg at the time of sacrifice. Similar animals receiving an 0.4 mg % or 2.0 mg % choline diet and older rats (140 g) surviving 10 days of similar diets did not have demonstrable hypertension at sacrifice 6 months later.