Abstract
Summary and Conclusions
The lymph nodes from animals that received serum from patients with chronic myeloid leukemia have a tendency to the same loss of lymphoid structure that is seen after the use of cortisone or ACTH; however, an increase in fibrosis and underlying connective tissue is also apparent. In these nodes, too, there is some slight increase in polymorphonuclear neutrophiles. The nodes from the 2 groups that received sera from patients with chronic lymphoid leukemia, Hodgkhrs disease and monocytic leukemia all showed a tendency to increased lymphoid production, although the third group (Hodgkin's and monocytic leukemia) also showed some increase in fibrosis. In both these groups a definite increase in eosino-philes occurred. Probably the lack of increase in underlying connective tissue in the “lymphoid group” segregates it from the “myeloid and the Hodgkin's monocytic groups.” The nodes from the animals that received sera from normal individuals showed on the whole nothing unusual.
The sera of patients with chronic myeloid leukemia bring about changes similar to those ascribed to cortisone itself or as initiated in action by ACTH in so far as the lymph node change is concerned. Myelokentric acid brings about similar lymph node changes and, as does cortisone, it also brings about increases in erythropoiesis, myelo-leukopoiesis and platelet formation. We do not, however, believe that it is cortisone.
The increased lymphopoiesis in the lymph nodes of animals that received serum from patients with chronic lymphoid leukemia is similar to that which we have described in animals that have received Lymphokentric acid in urinary extracts.
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