Abstract
Summary
1. Cortisone and ACTH prolong life and reduce the hemorrhagic manifestations of scurvy in guinea pigs. The effects of the two hormones are similar. 2. The effect of these two hormones is also parallel in the direction of maintenance of glycogen storage in liver, adrenal, and muscle in the scorbutic guinea pig. 3. The moderating effect of ACTH on scurvy makes it seem probable that vitamin C is not needed for the production of the corticosteroids similar to cortisone. This idea receives further support from other observations, including the demonstration of increased adrenal activity induced by ACTH in the absence of demonstrable adrenal ascorbic acid. 4. The locus of action of adrenal corticosteroids in the amelioration of certain hemorrhagic phenomena is not clear, but may be on the blood vessels or perivascular tissues.
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