Abstract
Summary
The intracellular distribution of pantothenic acid and of coenzyme A have been determined in normal rat liver and in azo dye-induced rat liver tumors. These substances were also determined in three kinds of transplantable rat tumors. All of the tumors were very much lower in these components than normal liver. The majority of each factor in the liver was contained in the mitochondria; however, in the liver tumor the supernatant fraction contained the largest amounts. The remaining amounts were distributed between the nuclear and supernatant fractions of the liver and the mitochondrial and nuclear fractions of the liver tumor. The microsomes from each tissue contained only small amounts of the vitamin and coenzyme. The finding that these tumors contain low levels of coenzyme A is in harmony with the observation of Potter and his associates that homogenates of such tumors contain low amounts of the enzymes that oxidize oxalacetic acid.
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