Further Studies on the Thermostable Leukocytosis Factor of Exudates

Abstract

Discussion and conclusions

The significance of the thermostable leukocytosis factor as a contributing factor in the mechanism of leukocytosis with inflammation has already been pointed out(3). At the time no conclusion could be reached as to whether the thermolabile LPF and the thermostable leukocytosis factor are one and the same substance, or whether the two factors are distinct entities. The present studies bearing on the nitrogen content of the crystals of the thermostable leukocytosis factor support the view that the two factors are two distinct substances.

In conclusion, the thermostable leukocytosis factor, recovered especially from acid exudates, and which is found in association with the pyrogenic factor, pyrexin, has been crystallized, and the crystals as such have essentially neither pyrogenic nor leukopenic properties. The crystals of the thermostable leukocytosis factor induce a leukocytosis characterized by a discharge into the circulation of immature 1-lobe form of granulocytes.