Abstract
Summary and conclusions
(1) Prodigiosin was employed in the range 1:20,000,000 to 1:100,000 against two distinct strains of E. histolytica.
(2) The monobacterial culture (NRS strain grown with A. aerogenes) proved more susceptible, failing to survive at 1:400,000. The mixed culture (UC strain) failed to survive at 1:100,000, even with relatively huge inocula of amoebae.
(3) Analysis disclosed that the bacterial flora, oxidation-reduction potentials and pH were not adversely affected by the experimental treatment.
(4) The general conclusion is reached that prodigiosin exerts a profound, direct action against E. histolytica in vitro. This is apparently the first record of proved direct action of an antibiotic against E. histolytica.
Get full access to this article
View all access options for this article.