Effect of Sulfasuxidine on the Interrelation of Folic Acid,Vitamin B 12 and Vitamin C. ∗

Abstract

Summary

The administration of sulfasuxidine eliminates the growth response produced by vitamin C in the chick, on a semi-purified ration. No effect is observed on the growth response produced by vitamin B₁₂, if the levels of the other B vitamins are adequate.

The administration of sulfasuxidine to a semi-purified ration eliminates the increase of the PGA liver storage produced by vitamin C. Both vitamin C and vitamin B₁₂ raise the caecal concentration of PGA in the chick. The administration of sulfasuxidine lowers the caecal levels of PGA to a minimum in all cases. Sulfasuxidine has no effect on the caecal level of vitamin B₁₂ in the chick.

Vitamin C, when injected, has no effect on growth, liver storage or caecal concentration of PGA in the chick. The injection of PGA markedly increased the liver storage and caecal levels of both PGA and vitamin B₁₂.