Experimental Histoplasmosis. Susceptibility of Male DBA Line 1 Mice By Various Routes of Injection

Abstract

Summary

In a series of experiments it has been shown that male dba line 1 mice are relatively resistant to intravenous injection of the yeast phase of Histoplasma capsulatum. Intraperitoneal injection of enormous numbers of the organisms suspended in saline produced occasional deaths. Intraperitoneal injection of approximately the same numbers of viable organisms suspended in 5% mucin increased the death rate. Intracerebral injection, however, was far superior to any of the other routes employed, both with respect to the numbers of organisms necessary to produce death 30 days after injection and the percentage of fatalities obtained within this period of time.