Abstract
Summary
1. The effects of daily administration of 50 or 100 mg of dl-ethionine on the rat pancreas is described.
2. Degenerative changes in the acinar tissue occurred as early as 12 hours after a single injection of 50 mg dl-ethionine.
3. Daily injections of 50 or 100 mg in non-fasted rats, for 2 weeks, resulted in almost complete obliteration of the acinar tissue accompanied by fibrous proliferation.
4. No histological evidence of islet damage was observed with these dosages.
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