Abstract
Summary
Antipyrine is distributed evenly in the various tissues of animals in close proportion to their water content. The values obtained for total body water by antipyrine and by desiccation agreed well and gave a correlation coefficient of 0.93. The rate of transformation and excretion of antipyrine as determined by plasma analysis was constant over a period of time sufficient for analysis.
Ease of analysis and lack of toxicity make antipyrine a suitable substance for use in measurement of total body water in animals.
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