Abstract
Summary
‘Benemid', p-(di-n-propylsul-famyl)-benzoic acid, inhibits the conjugase responsible definitively for the over-all reaction involved in the conjugatior of glycine with p-aminobenzoic acid. It was demonstrated that the compound did not decrease the availability of energy derived from the phosphate cycle, which is a coupled component of the conjugative reaction, since ‘Benemid' did not inhibit glucose phosphorylation by phosphorylase plus preformed ATP.
The implication of such conjugative reactions was discussed and several pharmacological and clinical applications of the anti-catabolite hypothesis were indicated.
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