Effects of Phosphorus 32 on the Hamster

Abstract

Summary

Effects of intraperitoneal injection of the hamster with phosphorus³² are described. Animals treated with 10 μc/g of body weight died in 11 days, there were no apparent changes in the testis at this time. Toxic effects were observed in animals injected with as little as 6 μc/g. Damage to the testes of animals treated with 6 and 8 μc respectively, was extensive, consisting of marked decrease in size, absence of spermatogenic cells in tubules, and actual damage to the tubules themselves, suggesting permanent sterility. No changes in the testes of animals treated with 1 μc/g were apparent in 24 hours. However, some damage was observed 30 days after treatment with 1 μc. Spermatogenic cells were more sensitive than Sertoli cells. Some interstitial cells appeared to be affected.