Abstract
Summary
1. 42 compounds, of which 39 could be classed as triazines and 3 as ethylenimine ring compounds were screened for chemotherapeutic activity against Ak4 mouse leukemia. 2. 2,4,6-triethylenimino-s-triazine, 2,4-diethylenimino - 6 - amino - s - triazine, and hexamethylene diethylenurea significantly prolonged the survival time of mice injected with transplanted leukemia Ak4. 3. It would appear that the chemotherapeutic activity of the above compounds can be attributed to the ethylenimine structure. 4. Four other compounds containing either a triazine or an ethylenimine moiety showed a slight chemotherapeutic effect.
Get full access to this article
View all access options for this article.