Abstract
Summary
Glutathione, when injected into normal animals which had been force-fed a high carbohydrate diet, induced glycosuria. The amount of glycosuria decreased with increasing adaptation to the high carbohydrate diet and after feeding the diet for 2 months, glutathione produced insignificant effects. By contrast the injection of glutathione into cortisone-diabetic rats caused a marked (in some cases up to 10 fold) increase in glycosuria which has been observed even after 3 months of the high carbohydrate diet. Cysteine and ascorbic acid were also studied. Glutathione potentiates the diabetogenic effect of cortisone. The mechanism of this potentiation has been discussed and its possible significance in the treatment of rheumatic disease has been suggested.
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