Abstract
Summary
Similar to carinamide, 3-hydroxy-2-phenylcinchoninic acid causes higher concentrations of penicillin in the plasma when injected before the administration of the penicillin. Both substances also decrease the rate of excretion of phenol red. The activities of the two drugs are roughly of the same order of magnitude. This increase in concentration of penicillin in the plasma and decrease in rate of excretion of phenol red is attributed to a blocking of the renal tubular secretory mechanism.
We wish to thank Sara Ann Verplanck and Irene T. Payne for technical assistance.
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