Abstract
Summary
1. Administration of testosterone propionate in daily doses of 0.25 and 0.5 mg, respectively, following exposure of mice to the LD50 of X-ray, up to 14 days, markedly increased the lethal effect of irradiation. 2. No changes in the X-ray induced organ effects were accomplished in all investigated organs with the exception of the liver. Radiation induced accumulation of sudanophile fat in this organ was definitely suppressed with larger dose of testosterone. 3. Radiobiological and some clinical implications of these findings are discussed.
The author is greatly indebted to Dr. J. P. Flynn, Head of the Psychology and Statistics Division of the Naval Medical Research Institute, for statistical analysis. Valuable technical assistance was rendered by Miss Gloria Schonwit at the Long Island College of Medicine.
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