Abstract
Summary
Data presented on the comparative toxicity of Thiomerin, Mercuhydrin and Mercurophylline indicate that the compound containing the thiol group definitely is more toxic in rats. Other reports, both clinical and laboratory, have indicated such a possibility. Sodium Thioglycollate potentiates the chronic toxicity of Mercurophylline when combined with it and given by either the subcutaneous or intravenous route. There is, however, elimination of the acute cardiac effect with intravenous administration. Studies of the distribution of mercury in the rat and its excreta following subcutaneous administration of two of the drugs failed to indicate the mechanism of potentiation of toxicity.
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