Abstract
Summary and Addendum
Crystalline alpha estradiol may be dissolved in acetone solutions of collodion and the steroid incorporated in or on the collodion particles, prepared in the usual manner. Such particles are biologically active as shown by the onset of a cornified vaginal smear in spayed or immature mice and rats. Furthermore, the hormone stimulation appears to persist for prolonged periods, presumably due to the slow elution of the alpha estradiol from the collodion particle.
The alpha estradiol-sensitized collodion particles were active after a storage period of four and one half months in the refrigerator. This was established by the onset of cornified cells in spayed rats.
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