Abstract
Summary
The administration of ACTH appears to have produced morphologic changes in the anterior pituitary of two patients. These changes consisted of an increase in the total number of basophiles, Crooke's hyaline cytoplasmic changes in these cells and basophilic stippling of many of the chromophobes. It is possible that these changes reflect the storage of endogenous ACTH following stimulation of the adrenal cortex by the therapeutic administration of this hormone.
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