Abstract
Summary
A study of the effect of physical factors on radiosodium clearance in dogs is reported. The average clearance rate in 25 control intramuscular injections was 59.4% activity remaining after 10 minutes. Decreases in intramuscular clearance rates were demonstrated with application of ice-salt mixtures, radiant heat and pressure cuffs. The average subcutaneous clearance rate in 10 control studies was 75.8% activity remaining in 10 minutes. This rate of clearance was increased with the addition of hyaluronidase. The clearance of radiosodium from a part does not appear as a straight line function when plotted and the calculation of per cent activity remaining per unit time is suggested as an expression for determination of clearance rates. The present study entirely supports the view of Kety that this technic is applicable to measure the effective circulation of a tissue and indicates the need for further study to quantitate the procedure for clinical application.
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