Abstract
Summary
1. We have determined PAH and mannitol clearances by the slope method without urine collection in 17 experiments, on 16 patients, comparing the results with urine clearances simultaneously measured.
2. Values of PAH clearance determined by the slope method and based on the volume of distribution either of PAH or mannitol, failed to be confirmed consistently by simultaneously measured urine clearances. PAH slope clearance agreed more often with urine clearance when the slope clearance was based on the volume of distribution of mannitol than when based on the volume of distribution of PAH. This agreement occurred too frequently to be fortuitous.
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