Abstract
Conclusion
Diphenhydramine was found to convert the vasodepressor effect of epinephrine and arterenol in the dog under adrenergic blockade with SY-28 to a vasopressor effect. The para-methyl substituted derivative of diphenhydramine as well as cocaine, tripelennamine, pyranisamine maleate, dtubocurarine, dibutoline and ergotamine can produce the same effect. Atropine (anticholinergic), papaverine (antispasmodic) and 2-N-propoxy-4, 6-diamino-s-triazine (antihistaminic) are ineffective. An inhibition of the vasodepressor mechanism is suggested as a possible made of action of these compounds on the reversal of the vasodepressor response and the potentiation of the vasopressor response to epinephrine and arterenol.
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