Abstract
Conclusion
The administration of Fraction IV-7 of plasma to 4 patients with severe Mediterranean anemia resulted in a consistent rise in serum iron values in all, and in a transitory appearance of a latent capacity to further bind iron in 3 of the 4 subjects. These observations suggest the release of iron from the tissues to the blood when additional metal-combining globulin is supplied in this disease. Further studies are in progress to explore the clinical value of Fraction IV-7 both in Mediterranean anemia and exogenous hemochromatosis associated with multiple transfusions.
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