Abstract
Summary
By use of a quantitative method for the determination of gastric secretory inhibitors the observation of Brunschwig and co-workers that the intravenous injection of alcoholic precipitates of achlorhydric gastric juice from patients with pernicious anemia depresses gastric secretion in dogs has been confirmed. The secretory depressant activity in such juice was shown by Brunschwig and his collaborators to reduce the secretion induced by feeding a meal. In this study it was found to be effective in inhibiting secretion provoked by histamine. The gastric secretory inhibitor was found in high concentration in achlorhydric gastric juice of persons without other demonstrable abnormalities in the gastro-intestinal tract or disease of the hemopoietic system. The gastric secretory inhibitor was absent or present in lower concentrations in gastric juice from normal individuals.
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