Abstract
Summary
Twenty volunteers were inoculated with the egg-adapted strain of CTF living virus. Reactions ranged from enlarged, tender axillary lymph glands to single-episode attacks of illness resembling Colorado Tick Fever. Five of the inoculated individuals were subsequently challenged with a human strain of CTF living virus but they showed no reactions whatsoever to this second inoculation. All of the individuals developed neutralizing antibodies, but the 3 who presumably were immune prior to the inoculations showed a comparatively earlier and greater response. Sera obtained from the 3 individuals after they had been challenged with a human strain likewise showed a high neutralizing titer.
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