Abstract
Conclusions
Procaine paralyzes first the parasympathetic and later the sympathetic synapses. Procaine suppresses the nicotinic and muscarinic effects of acetylcholine on the heart, but not the muscarinic effect of acetylcholine on the blood vessels. Procaine curarizes first the intercostal respiratory muscles, then the diaphragm and finally the skeletal muscles. Physostigmine, dimethyl-carbamate of hydroxy-phenylbenzyl-trimethylammonium (Nu-683) or di-isopropylfluorophosphate (DFP) suppress the paralyzing effects of procaine on synapses, on postsynaptic cardiac innervation and on neuro-muscular junctions, while procaine protects against most symptoms of intoxication induced by physostigmine, Nu-683 or DFP.
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