Abstract
Summary and Cnclusions
Twenty strains each of E. Coli, Aerobacter aerogenes, Pseudomonas, and Proteus vulgaris were tested for sensitivity to neomycin, Q-19, aureomycin, chloromycetin, and Polycyxin B. Q-19 and polymyxin B were particularly effective against Pseudomonas. Neomycin and chloromycetin were most effective against Proteus. Only 5 of the 80 strains tested were not sensitive to 31.2 μg or less of neomycin.
The degree of resistance possessed by variants exposed to Q-19 and neomycin is low. These variants display the “penicillin” rather than the “streptomycin” type of drug resistance.
Q-19 and neomycin are bactericidal in a concentration equal to or only slightly higher than that in which they are bacteriostatic.
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