Abstract
Summary
The hyperglycemic activity of certain fractions derived from the 15% sodium chloride supernatant, a by-product of insulin manufacture, was determined'before and after alkaline inactivation of the insulin present in these preparations. Hyperglycemic activity was studied in the rabbits but the results were interpreted only qualitatively, since a satisfactory log dose-response was not obtained. The factor was active Whether intravenously or subcutaneously administered. Repeated subcutaneous administration produced hypoglycemia and convulsions in some animals. The factor appeared to be stable in heparinized blood at 37°C for 1 hour; incubated blood itself produced a delayed hyperglycemic effect when injected intravenously. The factor did not protect mice against insulin-induced convulsions, but did reverse the hypoglycemic effect of insulin in the rabbit.
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