Abstract
Summary
Total, inorganic, and organic iodine of the tissues of normal and ANTU-poisoned rats was measured. ANTU decreased the thyroid iodine of rats and guinea pigs and caused a small increase in the total iodine of blood and lung when acutely toxic doses of the rodenticide were administered. Feeding a high iodine diet for 5 days caused a marked increase in the total iodine of tissues from normal and thyroidectomized rats. Since pre-treatment of thyroidectomized rats with iodine does not afford protection against ANTU the increase in thyroid iodine of normal iodine-fed rats appears to be involved directly in the prophylactic effect of iodide against ANTU poisoning.
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