Abstract
Summary
1. The administration of PGA to the guinea pig may lead to the development of casts in the renal tubules and to dilation of the obstructed nephrons.
2. The lesions may develop with parenteral doses of 1 mg of PGA daily for 21 days.
3. With daily parenteral doses of 5 mg of PGA the lesions may develop in 5 days.
4. The formation of these casts is not related to the feeding of tyrosine.
5. Scurvy is not a prerequisite for the appearance of the injury.
6. The lesions were not observed to occur on a stock diet containing cabbage. It appears that such a diet offers some protection against the development of the injury.
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