Abstract
Summary
Studies on the metabolism of the 8-aminoquinolines, pamaquine, isopentaquine, primaquine, pentaquine, SN 13,058, and CN 1100, have been carried out in the rhesus monkey. As shown by differential analyses of the 8-aminoquinoline contents of plasma, each of the above compounds is degraded to alkali-soluble, ethylene dichloride-insoluble derivatives. This degradation follows either oral or intramuscular administration of the drugs. The extent of degradation of the different compounds varies markedly, being greatest with CN 1100 and least with SN 13,058. Preliminary studies on CN 1100 have indicated that the degradation products of this compound are present in the urine in considerable quantity.
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