Abstract
Summary
1. The duration of hypnosis of pentobarbital sodium was increased for mice by all 11 surface active agents tested.
2. Aresklene 400 was selected for study on other animals. It increased the time of hypnosis due to pentobarbital in rats and rabbits but not in dogs.
3. Thiopental sodium showed an increase in effect with some of the surface active agents but not all.
4. Aresklene 400 increased the activity of thiopental apparently by decreasing the rate of destruction of thiopental in the body.
5. The onset of hypnosis but not the duration of hypnosis was influenced by Aresklene 400 with sodium barbital. Aresklene 400 decreased the time of onset of hypnosis when given with barbital sodium in mice, rabbits, and dogs but not in rats. Six of 10 other agents studied only in mice had the same effect on onset of hypnosis.
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