Abstract
Summary
1. Male albino rats weighing between 100 and 250 g were poisoned with mercuric chloride and treated with BAL, testosterone propionate or a combination of both.
2. It was demonstrated that in rats as in other species BAL effectively combats the toxicity of mercuric chloride.
3. Testosterone propionate over a wide range of doses administered after mercuric chloride had no apparent effect upon the toxicity, either alone or in combination with BAL.
4. Histologic study of the kidneys failed to demonstrate any stimulating effect of testosterone on the damaged tubules. The definite protection afforded by BAL could not be correlated with any detectable microscopic changes in the tubules.
Get full access to this article
View all access options for this article.