Abstract
Summary and Conclusions
H. capsulatum in the yeast phase when suspended in 5% hog gastric mucin and administered intraperitoneally into white mice caused a high percentage of fatal indections. Equivalent challenge doses of the organism suspended in saline rarely caused dleath. It was observed that by varying the number of organisms administered in mucin the mortality rate as well as the time interval between injection and death could be altered to suit the experimental requirements.
Certain investigations on experimental histoplasmosis heretofore have been limited by the relative resistance of white mice to infection with H. capsulatum. “Virulence-enhancement” by mucin offers a means of extending the scope of such studies.
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