Abstract
Summary
Tripelennamine (Pyribenzamine) was estimated by the Brodie methyl orange technic which was modified to give a high degree of specificity. The compound is rapidly and completely absorbed by rats following oral administration. It rapidly leaves the blood and localizes in all tissues especially lungs. Brain, kidneys, spleen, liver and heart all may concentrate appreciable amounts, the level of tripelennamine present in each organ being somewhat dependent upon its mode of administration. High brain levels of tripelennamine were consistently noted with lethal doses of the compound. Prolonged storage of the compound does not occur and only small amounts are excreted via the urine and feces. It is concluded that the compound is almost completely metabolized in the body. The liver subsequently was found to be the most active organ for metabolizing tripelennamine.
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