Effect of Vitamin B 12 on Experimental Hepatic Injury. ∗

Abstract

Summary

Vit. B₁₂ (1 γ daily, by mouth) had no effect on the development of massive hepatic necrosis in rats fed experimental rations with yeast as sole source of protein.

Vit. B₁₂ (0.5 γ daily by mouth) has shown significant lipotropic activity in rats fed a low protein-low fat ration. Under the experimental conditions chosen methionine was more effective than vitamin B₁₂ in preventing fat deposition in the liver. A low protein-high fat diet seemed to interfere with the lipotropic effect of B₁₂.