Abstract
Summary
(1) Desoxypyridoxine has been shown to exert a powerful antipyridoxine effect in the mouse. With the aid of this substance, typical symptoms of vitamin B6 deficiency (acrodynia) have been produced in this species. (2) A high casein level in the diet was found to have a detrimental effect on the acrodynia thus produced, but not to the same extent as that observed in the case of the acrodynia of vit. B6 deficient rats, not receiving desoxypyridoxine. Methionine, in amounts equivalent to those present in the casein, had a corresponding detrimental effect. (3) The pyridoxine requirement of the mouse was found to be, under the conditions of our experiments, between 1 and 2 γ per day. (4) For mice receiving 2 γ pyridoxine per day, the inhibition index of desoxypyridoxine was found to be 10. (5) Methoxypyridoxine acts as a pyridoxine precursor in the mouse.
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