Abstract
Summary
Milibis is almost completely non-toxic when administered orally to rats. A dose of 10 g/kg/day for 18 of 21 days inhibited growth only slightly, and at this dose level the mortality was 20%; with smaller doses there was no inhibition of growth, and no mortality attributable to the drug. Absorption was studied in human subjects and rats, during and following repeated oral administration. Both species excreted in the urine at most 2 to 4% of the ingested As. Human subjects excreted no detectable Bi in the urine, but the rats excreted about 1% of the amount ingested. In the rats tissue concentrations of both As and Bi were negligible, as was the As concentration in blood.
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