Abstract
Summary
The results of the various experiments did not provide any evidence that Pyribenzamine protects against systemic tuberculin shock in the tuberculous guinea pig.
This is in contrast to the marked protection Pyribenzamine affords against active anaphylactic shock where as little as 1 mg/kg given subcutaneously 10 minutes before the shock dose of antigen may give full protection against fatal anaphylaxis( 7 ). In our own experience, several properly-spaced doses of Pyribenzamine totalling 4 to 8 mg/kg given subcutaneously at intervals before and after a large shock dose of antigen prevents severe shock and death from both acute and protracted active anaphylaxis in the majority of highly sensitive guinea pigs( 8 ).
The failure of Pyribenzamine to protect against systemic tuberculin shock is perhaps to be expected since no smooth muscle reaction or shock organ has ever been identified as taking part in this type of shock.
The results of the present experiments indicate that histamine or histamine-like substances do not play a significant role in tuberculin shock and support the concept that anaphylactic and tuberculin sensitivities are basically different.
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