Abstract
Summary
In both hemophilic and thrombocytopenic blood the defect of the clotting mechanism reflects a deficiency of active thromboplastin. Addition of thrombocytopenic blood to hemophilic blood results in a mixture in which the clotting time, clot retraction, prothrombin activity and “accelerator effect” of serum all become normal.
These findings support the theory that at least two factors are necessary for the formation of active thromboplastin: a plasmatic agent, deficient in hemophilia, and a platelet factor, defective in thrombocytopenic purpura.
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