Abstract
Summary
Proliferating epithelial cells and fibroblasts, and cells from explants of embryonal brain tissue are retarded in growth in vitro by concentrations of chloramphenicol and aureomycin of 10 γ/ml and completely inhibited from growing by concentrations of 1,000 γ/ml. The concentrations required for appreciable inhibition of growth of cells are somewhat in excess of those which are bacteriostatic for most susceptible organisms but are within the range attained in the blood of treated patients. The amounts of the antibiotics required to produce toxic changes in the tissue culture cells are of the order sometimes reached in treating patients but those required for complete suppression of growth are well beyond clinical experience.
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