Abstract
Conclusions
1. Stilbamidine administered intraperitoneally to mice in doses of 4 to 20 mg (160 to 800 mg/kg) caused cessation of respirations in 4 to 6.5 minutes, accompanied by progressive and varying degrees of sinoauricular, auriculo-ventricular and intraventricular block eventuating in death. No significant ST-T changes occurred.
2. The constancy and reproducibility of the electrocardiogram in the normal mouse indicates that the effect of drugs upon the electrocardiogram may profitably be studied in this animal.
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