Abstract
Summary
In contrast to its excellent effect in stimulating cartilaginous and osseous growth in the rat's penile ossicle, testosterone propionate, in a daily subcutaneous dose of 0.1 mg for 21 days following hypophysectomy and castration, caused no appreciable resumption of general skeletal growth. Somatotrophin (hypophyseal growth hormone) in a daily subcutaneous dose of 1.0 mg for the same period in similar animals caused excellent general skeletal growth, but did not correct appreciably the atrophic condition of the os penis. The two hormones synergized in causing better growth of the os penis than the androgen alone and a greater body weight increase than the growth hormone alone in doubly operated animals.
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