Abstract
Summary and Conclusions
1. 21-Acetoxy-pregnenolone was selected for a limited study in 7 ambulatory patients with rheumatoid arthritis because in the rabbit synovial membrane screen it was at least as good as cortisone in decreasing permeability and it showed powerful anti-DOCA action on synovial membrane.
2. The effect on the end organ seen in the screen in rabbits manifested itself in each of the seven patients by reduction in swelling, lessening of the pain, and increased motion in the joints.
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